Despite its extensive use, MADRS lacks published results in Brazil, precluding comparisons against the findings of the present study.
Drug ionisation in acidic environments may subsequently result in reduced lipophilicity, precluding maximal potential sequestration to circulating lipid particles.
Because they are essential genes, mutations result in embryonic lethality precluding extensive characterization.
As a consequence, difficulty exists in comparing results, precluding meta-analysis [ 30].
This work justifies the use of the nanoindentation technique over conventional microhardness tests for reliable measurement of hardness of chemical vapour deposited (CVD) diamond coatings as microhardness testing resulted in localised damage precluding accurate measurement.
Whole-body deletion of endothelial-expressed genes in mice often results in embryonic lethality precluding analyses of endothelial cell function in the maturing glomerulus.
However, previous attempts in our laboratory using IVF with these spermatozoa resulted in polyspermic zygotes, precluding embryo development (Sjunnesson YCB, González R and Morrell JM, unpublished observations).
The role of the other catalytic subunits has not been directly addressed as loss of p110α and p110β results in embryonic lethality, precluding analysis of their roles in mammary gland [ 3].
Moreover, the limited number of ligand knockout mouse lines in existence result in developmental defects that preclude analysis in the adult [ 3- 5], and tissue-specific analyses are impeded by the lack of available knockout mice with conditional alleles.
We consider that this western blot result does not preclude mitochondrial accumulation in MSA oligodendroglia observed in immunohistochemistry, as the TOM20 protein level can be influenced not only by oligodendroglia, but also by many other cells including astrocytes, microglia and neuronal processes that express TOM20.
