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Interestingly, the triggering of TLR3 by dsRNA can result in attenuation of the TLR4 pathway [54].
1A, anti IL-7 antibody treatment of WT mice did not result in attenuation of CD8+ T cell response against T. gondii.
It may be that such an approach might result in attenuation of clinical symptoms of patients with this or similar mutations.
These modulations can result in attenuation of the inflammatory response and deactivation of the macrophage aiding the parasite in the establishment of infection.
Though the functional consequences of Ste7 phosphorylation by Kss1 are not clear, Maleri et al. [34] have shown that it does not result in attenuation, as had been assumed previously [35].
Taking into consideration our results that loss of virulence associated with the Beaudette strain resides in the replicase and the results of Ammayappan et al. [47], it is possible that very few amino acid substitutions within the replicase gene can result in attenuation following serial passage in embryonated eggs.
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Conclusion Administration of EA-230 is safe and results in attenuation of the systemic inflammatory response in humans.
Consistent with the results of Ad-BMAL1 expression, knockdown of BMAL1 by Ad-BMAL1i resulted in attenuation of G6Pase-luc activity in primary hepatocytes (Fig. S2D).
Deletion of either gene (GBAA0552 or GBAA1340) resulted in attenuation in a murine model of infection.
siRNA targeting of STAT3 resulted in attenuation of the enhanced cardioprotection of TLR4-deficient MSC.
Its deletion results in attenuation of viral growth and RNA synthesis [17].
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