These mutations frequently result in activation of its kinase activity [ 110].
The corresponding mutations result in activation of the PI3K catalytic activity and constitutive downstream signalling.
In addition multiple other TLR independent pathways which are activated by pathogen recognition can result in activation of IRF3 [ 84].
Reduced levels of tryptophan activate the amino acid sensitive GCN2-kinase pathway and result in activation of Tregs[ 32].
Genetic abnormalities in cancers frequently result in activation of PKB, by loss of the tumor suppressor PTEN or by activating mutations of PI3KCα.
Each of these conditions can result in activation of the hypothalamic-posterior pituitary system and stimulation of vasopressin release independent of the usual regulatory factors.
Inhibition of p53-MDM2 binding would result in activation of the tumour suppressor.
These calcium-dependent signalings may result in activation of expression of the genes responsible for aerenchyma formation (Drew et al. 2000; Subbaiah and Sachs 2003).
This effect occurs due to the strong overlap between the metal nd orbitals and gas molecule orbitals, result in activation of the adsorbed gas molecules.
During early development, they mediate depolarizing effects, which result in activation of calcium-sensitive signaling processes that are important for the differentiation of the brain.
HMDMs incubated with Yersinia did not result in activation of any caspase tested until ∼6 h (Fig. 2).
