Sentence examples for result in activating from inspiring English sources

Theoretically, this would result in activating the canonical Wnt pathway by losing NKD1's negative regulatory effect in the pathway.

In Arabidopsis, the upregulation of metacaspase type II could result in activating the downstream proteases, whereas proteases are required to mediate cell death via oxidative stress [ 50].

Because cellular DNA damage and particularly the induction of DSBs result in activating phosphorylation of ATM at Ser-1981 and Histone H2AX at Ser-139, we also explored whether the Ser-139 Histone H2AX phosphorylation was altered in response to metformin.

Indeed, BAs are suggested to play an important role in host energy metabolism in brown adipose tissue through the activation of TGR5, resulting in activating type-2 iodothyroxine deiodinase and the stimulation of energy metabolism through increased levels of thyroid hormone.

This approach is based on the concept that scintillating nanoparticles, such as Tb3+-doped LaF3 crystal (LaF3 Tb), can locally convert X-ray into light and the emitted luminescences are able to activate the photosensitizers on the mechanism of fluorescence resonance energy transfer (FRET), further resulting in activating photosensitizer to induce 1O2 for cancer therapy [8].

Cellular DNA damage (particularly the induction of DSBs) results in activating phosphorylation of ATM at Ser-1981 and histone H2AX at Ser-139 [46].

The α-Lenolenic acid degradation pathway was firstly responded resulting in activating the JA-pathway inner tea leaves, and the MEP/DOXP pathway significantly exaggerated.

Hence, elucidating mechanisms by which suppressing androgen/AR results in activating downstream signalling pathways may have important implications for better therapeutic designs to control PCa progression instead of only targeting androgen/AR signalling.

In addition, treatment of SH-SY5Y cells with PGE2 (10 μ m) or forskolin (10 μ m) results in activating the PI3-K/AKT and PKA/CREB signaling pathways by phosphorylation of AKT at Ser 473 and CREB at Ser 133, respectively (Fig. 3F); this activation then stimulates the mRNA and protein expression of BACE-1 in SH-SY5Y cells.

The extrinsic pathway can be triggered to undergo oligomerization when proper ligands bind their respective death receptors, ultimately recruiting adaptor molecules and caspase-8 into a complex resulting in activated caspase-8.

They are the result of changes in activating systems located in lower brain centers and the finding of reduced arousals – hypoarousal – in CH patients suggests reduced activity of ascending projections from the thalamus, hypothalamus and brainstem to the cortex.