Sentence examples for result in activated from inspiring English sources

Mutations in FLT3 result in activated tyrosine kinase activity, cell growth stimulation, and a poor prognosis among various subtypes of leukemia.

It induces damage to muscle fibre membranes, 1 2 myofibrillar disruption 3 and sarcoplasmic reticulum vacuolisation. 4 Such exercise-induced muscle damage activates a cascade of reactions that result in activated skeletal muscle protein metabolism.

PTEN is a lipid phosphatase that reduces PI3K activity and hence an antagonist of insulin signaling, whose elimination will result in activated Akt and thus mTORC1.

Thus demethylation of different lysine residues may result in activated or repressed transcription.

Also exposure of TFK-1 and EGI-1 cells to equivalent amounts of Salinomycin did not result in activated caspase-3.

In transgenic mouse mammary tumours, receptor tyrosine kinase pathways result in activated Ras protein signalling [ 2], whereas hormone-sensitive MCF-7 breast cancer cells have been shown to express high levels of Ras-related proteins [ 3].

Theoretically, this would result in activating the canonical Wnt pathway by losing NKD1's negative regulatory effect in the pathway.

In Arabidopsis, the upregulation of metacaspase type II could result in activating the downstream proteases, whereas proteases are required to mediate cell death via oxidative stress [ 50].

Because cellular DNA damage and particularly the induction of DSBs result in activating phosphorylation of ATM at Ser-1981 and Histone H2AX at Ser-139, we also explored whether the Ser-139 Histone H2AX phosphorylation was altered in response to metformin.

The extrinsic pathway can be triggered to undergo oligomerization when proper ligands bind their respective death receptors, ultimately recruiting adaptor molecules and caspase-8 into a complex resulting in activated caspase-8.

Indeed, BAs are suggested to play an important role in host energy metabolism in brown adipose tissue through the activation of TGR5, resulting in activating type-2 iodothyroxine deiodinase and the stimulation of energy metabolism through increased levels of thyroid hormone.