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Hettinger argues that intellectual property "restricts methods of acquiring ideas (as do trade secrets), it restricts the use of ideas (as do patents), and it restricts the expression of ideas (as do copyrights)—restrictions undesirable for a number of reasons" (Hettinger 1989).
In addition MET1 restricts the expression of imprinted genes in endosperm to the maternal alleles, resulting eventually in a different type of maternal control of endosperm growth.
In this line, the use of the rat insulin promoter 2 to drive the expression of CreER restricts the expression of the recombinase to pancreatic β-cells.
The transcription factor TFII-I (Table 1) restricts the expression of β-globin to the adult stage of erythropoiesis thus maintaining the primitive phenotype of murine embryonic stem cells [41].
The PRC2 complex also restricts the expression of PHE1 to the chalazal domain of the endosperm after fertilization.
In intestinal epithelium, SHH represses canonical Wnt signaling, which restricts the expression of genes targeted by Wnt.
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Mesp2 also induced the expression of Ripply 1 and 2, which in turn played roles in restricting the expression domain of Mesp2 by suppressing the activity of Tbx6.
This approach exploits cellular gene regulatory elements that mediate cell type-specific transcription to restrict the expression of therapeutic genes or essential viral genes, ideally to cancer cells.
Recently, we were able to lower plasma homocysteine levels in mice with moderate hyperhomocysteinemia using an adenoviral construct designed to restrict the expression of DYRK1A, a serine/threonine kinase involved in methionine metabolism (and therefore homocysteine production), to hepatocytes.
However, the regulatory mechanisms that restrict the expression of this gene in the germ cells is largely unknown at present.
Negative feedback on TOR pathway function to restrict the expression of FLO11 under nitrogen starved condition and also with re-addition of nitrogen to starved cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com