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Early data from the TRICS trial in cardiac surgery also demonstrated a trend to increased adverse events including stroke (3 vs. 0) and death (4 vs. 1) in the restrictive study arm [46].
This kind of effect can be expected to contribute to an even greater cost-effectiveness than the net societal benefit of $230 million and 2,055 quality-adjusted life years demonstrated in a more restrictive study of SRTS in New York City (Muennig et al. 2014).
While a more restrictive study design could eliminate these problems, it would not portray youth welfare routines as accurately.
In the current study, the range of urine volume and osmolality observed despite the restrictive study conditions speaks to a strong individuality of intrinsic regulation of body water.
Overly restrictive study protocols often preclude the recruitment of older participants [ 58], and particularly people with cognitive impairment or multiple co-morbidities.
We explicitly decided to expand this review and will also include less restrictive study designs in addition to randomized and quasi-randomized trials, to provide a comprehensive theoretical basis.
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The restrictive studies have all used different strategies for restricting the total volume of fluids administered, with results ranging from improved outcomes through no difference to worse outcomes with restrictive practice [ 9, 10].
Although the assumption of symmetry is restrictive, studying the symmetric component of a general system's dynamic matrices provides bounds on the H2 and H∞ performance of the original system.
Interpretation of the myriad of available liberal versus restrictive studies is complicated by a complete lack of standardized definitions of liberal and restrictive.
The potential of construction lead analysis has never been considered so far, as most analytical methods prove restrictive to study large sets of samples.
To avoid to be extremely restrictive, in this study we use the false discovery rate (FDR) [17] as multiple hypothesis test correction.
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