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(Practitioner 11) The importance of this complex, adaptive treatment process based on continual feedback from multiple information sources was echoed in ideas expressed about TMB research based on restrictive protocols compared to clinical practice (Theme 4).
Based on the finding that a liberal regimen in one of the examined trials was reported to be only 10 ml higher [ 13] than a restrictive one in another trial [ 8], Doherty and Buggy concluded that due to the lack of well-defined liberal or restrictive protocols, respectively, the two expressions (liberal and restrictive) might be used and understood differently in different institutions [ 14].
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Conclusion: The introduction of a restrictive protocol based on the underlying cardiac rhythm in the setting of refractory OHCA has dramatically reduced the number of ECLS implantation.
With such a constitutional guarantee we would get to the end of a sad era in media-related laws that give governments monopoly over the airwaves, that place a restrictive protocol on newspapers and that licenses journalists through a close shop press syndicate.
The scope of this study was limited because of a restrictive protocol.
There is evidence that a more restrictive, protocol-based fluid management – best with goal-directed fluid administration – might lead to fewer complications, e.g. after abdominal surgery or elective colorectal resection, respectively [ 8- 10].
The incidence of ARDS decreased from 28%to10%10 % when applying a quality improvement intervention, namely setting VT at 6-8 ml/kg PBW in patients at risk of ARDS plus using a restrictive protocol for red blood cell (RBC) transfusion [ 36].
Widespread adoption of restrictive transfusion protocols in high risk patients may provide further reductions in rates of ALI.
Overly restrictive study protocols often preclude the recruitment of older participants [ 58], and particularly people with cognitive impairment or multiple co-morbidities.
General concerns with the RCTs for DrotAA are that they were tightly regulated, included a narrow range of patients and centers, applied restrictive treatment protocols, focused on short-term endpoints (28-day mortality), and did not collect cost data.
The checklist targets increased compliance with evidence-based practice in at risk patients (that is, aspiration precautions, early appropriate antibiotics and goal-directed therapy for sepsis, restrictive transfusion protocols, lung protective ventilation for intubated patients and restrictive fluid management after reversal of shock).
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