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Most investigators are used to a very restrictive phase III-type RCT, but policy evaluations are of a different nature.
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During the development of zidovudine, for example, the FDA implemented policies to speed up the more restrictive trial phase.
Concerning phase equilibria, no restrictive assumptions are made.
First, previously transfused patients were excluded; therefore, the safety of a restrictive strategy during the early phase of septic shock is still not explored and further study is needed.
The cdc25 mutant cells [34] were synchronously arrested in the G2 phase at the restrictive temperature (36°C) for 4 h, and then released into mitosis upon shifting to the permissive temperature (26°C).
(B ) The vac17Δ pep12-60 tsf double mutant arrests in G1 phase at the restrictive temperature 37°C.
These results indicate that the folA1 mutant is blocked in M phase at the restrictive temperature.
(D ) The vac17Δ pep12-60 tsf double mutant arrests in early G1 phase at the restrictive temperature, 37°C.
(C ) The vac17Δ pep12-60 tsf double mutant arrests in early G1 phase at the restrictive temperature 37°C.
(A ) The vac17Δ pep12-60 tsf double mutant is arrested in G1 phase at the restrictive temperature, 37°C.
The most serious drawback of bicellar phases is the fact that they are found in restricted regions of the phase diagram that are bound by limiting temperatures and hydration levels that may be restrictive for some application.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com