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The δ difference over placebo was >15%, and the number needed to treat was 7. The >75% rule is a more restrictive outcome measure and selects a smaller percentage of responders.
These more restrictive outcome measures have been previously used in the tegaserod 28 and linaclotide 35 trials and help to distinguish the 'sustained' responders to the active treatment from those responding to placebo.
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The aim of this study was to define which is the best transfusion strategy in septic shock patients regarding 28-day mortality and clinical outcomes: restrictive or liberal.
If the measures demanded are too restrictive, the most likely outcome would be to suppress growth in the economy, as aggregate demand is severely constrained.
It is shown that the widely-used approach of a revenue-neutral fixed feed-in tariff can yield an optimal outcome under restrictive conditions only.
The study of Lacroix and colleagues [ 1] confirms the results reported by two other randomized trials that evaluated the impact of a restrictive strategy on the outcome of critically ill adults [ 6] and preterm infants [ 7].
Through randomized clinical studies, the effect of more liberal or restrictive triggers on long-term outcome can be studied, as well as the combination with a low (10 ml/kg) or high (20 ml/kg) transfusion volume.
There are no prospective studies comparing outcomes between restrictive or liberal strategies in cardiac surgery.
Compared with a liberal transfusion strategy, a restrictive strategy significantly improved outcomes in patients with acute UGIB.
Being too restrictive in the secondary outcomes for the review would limit our understanding of these potential mechanisms.
Associations between postoperative fluid overload and poor survival have been shown in other studies, however, and better outcomes after restrictive fluid resuscitation regimens after surgery were reported [ 30- 32].
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