Third, restriction of analysis to articles published in English is another potential limitation.
26 The limitations of the present study include the restriction of analysis to the factors of gender and sports practice that were chosen at the study onset.
Restriction of analysis to the first pair of daughters, and their first pregnancies, resulted in only one record per family and thus independence within the material.
In addition, restriction of analysis to cases with an available clinic DS control did not significantly alter our findings for combined acute leukaemia and child infections.
The evidence base is characterised by studies in which well described randomisation, blinding of allocation or outcome assessment, intention-to-treat analysis and restriction of analysis to primary outcomes are the exceptions.
Restriction of analysis to stage IB+ cervical cancer made little difference to the point estimate, but resulted in a wider confidence interval and allowed for the possibility of a greater effect (1.03, 0.63 to 1.7) (fig 3B).
One caveat of our approach is that a missing KIR ligand does not imply an inhibitory KIR/HLA mismatch, however, restriction of analysis to the almost universally expressed KIR2D did not show significant differences.
After applying the aforementioned filter and restriction of analysis to exons with their adjacent 2 bps on each side, exome sequencing identified 21,741 SNVs in the germline DNA, 20,749 of which were in the Single Nucleotide Polymorphism Database (dbSNP132) and 992 were novel.
Considering mortality in the complete cohort, 4718/51 397 (9%) patients who were prescribed a statin at the index date died during follow-up compared with 32 445/308 730 (11%) not prescribed a statin, after restriction of analysis to patients within propensity score bands 9 to 19.
This lack of agreement between all three programs is perhaps unsurprising considering the different restrictions of each analysis.
The effect of allocation concealment on results was assessed through sensitivity analysis, with restriction of the analysis to studies with adequate allocation concealment.
