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Although restriction of population cross-comparisons to the HVS-I control region increases the number of available samples, it is important to note that some matches may involve sequences that are phylogenetically unrelated.
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Limitations of prior prostate cancer expression profiling studies have included small sample size, restriction of populations to surgical cohorts, short follow up time, and the use of surrogate endpoints such as PSA biochemical recurrence to define disease progression.
Hence, it is not only necessary to identify the individuals MHC genotype but also to tailor the epitope selection to match the MHC allele restrictions of a population (population-optimized vaccine) or that of an individual (personalized vaccines).
These limitations include restriction of the population of interest due to the strict inclusion criteria, restrictions in the nature of the intervention evaluated, restrictions in study-design and the measurement of outcomes.
Of note, incidence estimates from some other studies e.g. [ 2, 3, 9] should be interpreted with caution due to the restriction of the population to those with AIDS, a group potentially at higher risk of cancer due to their advanced stage of immunodeficiency [ 23].
The spatial restriction of resistant populations studied to date is likely a function of the distribution of the contaminants that historically elicited a toxic response and the relatively low mobility of affected populations.
**Do you think China could have achieved its epic growth of the past thirty years without restrictions on population growth?
Thus, we should present the results from the AHP under the restriction of their study population.
Another major limitation of our study is restriction of the study population to men only.
To better appreciate potential differences of intrauterine growth retardation during gestation and to better understand the interplay between preterm delivery and low birth weight, several sub-analyses have been performed including restriction of the study population to term deliveries and graphical depiction of birth weight for each week of gestation.
Some of the confounding factors will be minimised in the present study using restriction of the study population to adults admitted to particular hospitals.
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