Sentence examples for restriction of differentiation from inspiring English sources

Moreover, a picture is emerging of asynchronous expression of lymphoid genes and markers, with gradual restriction of differentiation options [8], [9].

It is reported that microRNAs are involved in physiological and pathological functions, such as the regulation of developmental timing and pattern formation [12], restriction of differentiation potential [13], chromatin rearrangements [14], and carcinogenesis [15].

Together with the previous evidence hinting that hematopoietic cells gradually restrict their signalling capacity with differentiation [ 28], these results indicate that the restriction of signalling capacity plays roles in the restriction of differentiation plasticity during differentiation.

The progressive restriction of the differentiation potential from pluripotent embryonic stem cells (ESC) to different populations of multipotent adult stem cells (ASC) depends on the orchestrated action of key transcription factors and changes in the profile of epigenetic modifications that ultimately lead to expression of different sets of genes.

Our results provide a direct connection between changes in the epigenetic signature and progression from pluripotency of ESC cells to restriction of the differentiation potential in MSC and ADSC, highlighting the existence of intermediate states of potency that exhibit specific epigenetic profiles.

These transcription factors function well before the appearance of any cortical interneurons and yet have profound effects on cortical interneuron development through restriction of progenitor differentiation potential.

Recent observations have demonstrated that adult somatic stem cells have the capacity to participate in the regeneration of different tissues [25], [26], thereby suggesting that restrictions on differentiation are not completely irreversible and can be reprogrammed with de-differentiation and trans-differentiation processes.

The findings of this study inform lecturers on how they should prepare lessons to guide students to understand and apply restrictions of certain differentiation rules and formulae.

Work in the Drosophila nerve cord (Cleary and Doe 2006), the vertebrate retina (Cepko et al. 1996), as well as the mammalian cerebral cortex (Desai and McConnell 2000), has provided evidence that neuronal progenitors can attain specific identities through progressive restrictions of their differentiation potential during development.

These combined findings suggest that HRG signals may contribute to growth restriction or differentiation of prostate epithelia.

"In particular, legislation of the Russian Federation does not stipulate any restrictions or differentiation of the rights and responsibilities of citizens on the basis of sexual orientation.