Sentence examples for restriction element from inspiring English sources

This was an interesting finding, since DRAG mice do not express HLA class I molecules, the restriction element for thymic differentiation of human CD8 T cells.

This approach allowed us to directly concentrate our efforts on naturally processed tumor antigen-specific epitopes presented by a given MHC class II restriction element.

An alternative is to use MAP specific epitopes and test for recognition of these in polyclonal T cell lines derived from intestinal biopsies of patients carrying the relevant HLA class II restriction element.

Using a panel of B-EBV transformed cells, we found that these specific CTLs recognized the cA1 peptide by the A*0201 class I MHC molecule, the same restriction element as the CTLs derived from gp160IIIB immunized donor BI.

To evaluate the vaccine induction of CD8 T-cell responses, 50% of the enrolled subjects were HLA-B7+ which is known to be the restriction element for the V3 (RPNNNTRKSI) CTL epitope.

To identify the restriction element we first tested the recognition by CD4+ T cells of peptide loaded autologous APC in the absence or in the presence of anti-HLA-DR, anti-HLA-DP and anti-HLA-DQ mAbs.

Since literature on this topic is sparse, a controlled bushing prototype which accommodates a combination of long and short flow passages and flow restriction elements is first designed, constructed and instrumented.

The CTL selection pressure exerted by HLA-B27 may not be greater than that exerted by other HLA restriction elements early in disease.

Because only a limited number of class II genotypes can function as restriction elements for the CS repeat epitope, it was not unexpected to find only 1 of 28 persons consistently respond to the HLA-restricted (T1B 4 antigen (Table 5).

Many studies have tried to correlate the magnitude and/or breadth of the CTL response with control of viremia in humans and for the majority of HLA restriction elements no such simple relationship exists.

When possible, optimal epitopes and/or HLA restriction elements were predicted for unmapped dominant responses (see Experimental Procedures).