We used only populations that contained at least 20 individuals, therefore restricting this analysis to the LGR (populations 1, 3, 4, 5, 15, 16, 17, 18, 21 and 25; Additional files 2 and 3).
For the GA simulation, this constraint can be easily satisfied by restricting the population space of the design variables within the above limits.
Consequently, the findings are restricted to this population group.
Notably, IL-10-producing Tr1 cells represent 10 15% of the polarized population, thus GZB expression is not restricted to this population of cells (Fig. 1B).
Efficacy assessment was deliberately restricted to this population as this was a postmarketing study in which we sought to determine objectively if subjects who used the rinse benefited.
Because all patients in our sample consulted a physical therapist and a medical doctor, our prediction model should be restricted to this population.
The pediatric clinics only care for patients less than 14 years of age, so the analyses were restricted to this population.
Furthermore, the patient population was predominantly non-surgical, and any conclusions are restricted to this population and the results of this study cannot be extrapolated to other patient types or all other ICUs in France, because the patient populations may be significantly different in other centers.
A significant factor restricting the population growth is rather a high level of migration.
We recalculated the validation statistics for the QFractureScores restricting the population to patients aged 40-85.
