Exact(14)
Under complete starvation condition, both cAMP-PKA and MAPK pathways do not get activated due to the absence of ammonium transport through Mep2, which along with complete loss of Tor activity contributed towards restricting the expression of FLO11.
As numerous metazoan elements display expression that is restricted to the reproductive apparatus, including the germ line and in surrounding somatic tissues, genomes have evolved specific mechanisms to protect these tissues by further restricting the expression of these elements.
This suggests that the conserved 21 bp promoter motif is important for restricting the expression of the CUC genes.
Tumors may be controlled by restricting the expression of OCT4, NANOG, and SOX2 or by disrupting the molecular pathways that are altered in CSCs.
In addition to the dorsoventral axis formation, cyp26 is also important for restricting the expression of posterior genes during the anteroposterior patterning [ 100].
This suggests that the presence of an uORF in MHX genes has some evolutionary advantage, possibly for restricting the expression of these genes.
Similar(46)
Hettinger argues that intellectual property "restricts methods of acquiring ideas (as do trade secrets), it restricts the use of ideas (as do patents), and it restricts the expression of ideas (as do copyrights)—restrictions undesirable for a number of reasons" (Hettinger 1989).
This approach exploits cellular gene regulatory elements that mediate cell type-specific transcription to restrict the expression of therapeutic genes or essential viral genes, ideally to cancer cells.
Recently, we were able to lower plasma homocysteine levels in mice with moderate hyperhomocysteinemia using an adenoviral construct designed to restrict the expression of DYRK1A, a serine/threonine kinase involved in methionine metabolism (and therefore homocysteine production), to hepatocytes.
In this line, the use of the rat insulin promoter 2 to drive the expression of CreER restricts the expression of the recombinase to pancreatic β-cells.
However, the regulatory mechanisms that restrict the expression of this gene in the germ cells is largely unknown at present.
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