Sentence examples for restricting gene expression from inspiring English sources
Restricting gene expression to specific cell subsets utilising tissue-specific promoter driven retroviral vectors is a challenge.
Tagging neurons with ChR2 provides a convenient mean for in vivo physiologists to exploit the growing list of methods available for restricting gene expression to defined neuronal populations.
This might be due to differences in epigenetic chromatin regulation, restricting gene expression to a pro-inflammatory programme and/or preventing phenotypic switching.
Restricting gene expression to a specified cell population within the brain by using cell-selective promoters remains an attractive approach [ 5, 6].
Spatially restricting gene expression by regulating local translation rather than by directing the delivery of mRNAs from nucleus to stimulated synapses maximizes the readiness of the entire neuronal arbor to respond to local cues.
By utilising Lck and CD19 restricted Cre transgenic bone marrow stem cells, we generate chimeric animals with T or B lymphocyte restricted gene expression respectively.
We find that while many eQTLs associated with human traits are shared between these two tissues, there are also examples where blood and brain differ, either by restricted gene expression patterns in one tissue or because of differences in how genetic variants are associated with transcript levels.
MET1 is a key player in the control of parental genomic imprinting, which restricts gene expression from one of the two parental alleles [10].
There are also indications that FGF signaling is required to negatively regulate and therefore restrict gene expression in the dorsal region of the embryo.
This shortcoming of tissue availability has largely restricted gene expression profiling studies in melanoma to the use of small numbers of established tumor cell lines and cases of metastatic disease.
In this report we describe two important new findings regarding the properties of the TCRα LCR and make a significant advance in our understanding of its capacity to generate T cell restricted gene expression.
