Sentence examples for restricting element from inspiring English sources

The ability of the wild-type sequence 861 874 to compete with a high affinity reference peptide for binding to I-Ed indicates that the escape of pathogenic NZB T cells from purging of the autoreactive repertoire cannot be attributed to ineffective presentation of peptide 861 874 by its restricting element.

It was therefore likely that the restricting element for the two novel epitopes was encoded by Mamu-B*08.

We are aware that the suggested restricting HLA class I alleles represent only the most likely restricting element, and that these assignment are merely based upon predictions.

Of these, the CD1d isoform has attracted particular attention because it is the restricting element for a subpopulation of T cells, called Natural Killer T (NKT) cells, that has potent immuno-modulatory properties [2].

Only a weak and not significant, effect of anti-CD25 mAb treatment was detected on the intensity of CD8+ T-cell responses specific to TB10.3 or TB10.4 immunogens, as judged by determination of percentages of such cells by the use of a pentamer of H-2Kd restricting element combined with TB10.3/4:20 28 peptide [30], [31].

Taking into consideration the overall responses we obtained, it may be more likely that in these particular cases HLA-A3 would represent the restricting element.

In addition to their role as restricting elements in antigen presentation, major histocompatibility complex (MHC) class II molecules can trigger intracellular signals after ligand binding in many cell types.

We next sought to determine the peptide specificities and HLA restricting elements responsible for CD8+ T-cell-mediated killing of autologous HIV-infected CD4+ T-cell targets in B*27/57 neg LTNP/EC.

It remains difficult for us to completely integrate our books for e-reading, and we still need to restrict elements of some of the work we publish when creating an eBook.

This agrees with the genomic nature of histone modifications defining these states, which mark spatially restricted elements (e.g. promoters or enhancers; cs1) or wider areas such as H3K27me3 domains (cs8) or entire H3K36me3-marked coding regions (cs6).

CD5 levels on T cells have been linked to adaptation and fine-tuning of T cell responsiveness [ 12, 51], possibly via tonic signaling through the restricting MHC element which has been shown to be required for naïve T cell survival, maintenance and homeostatic proliferation in lymphopenic environments [ 52].