These results imply that the age-related regulation of CTGF and TSP-1 expression by miR-18a and miR-19b in the heart is uniquely restricted to the cardiomyocyte to control its surrounding ECM.
To determine if the HBV/E strains that are uniquely restricted to the HBV/E crescent are adapted to the populations in that region, we calculated overall and site-by-site selection pressures acting on the four ORFs in the 47-HBV/E whole genomes.
It is therefore tempting to speculate that in addition to unique P-box and D-box sequences and to a spatial expression uniquely restricted to photoreceptors, NR2E3 dimer formation can increase target specificity when compared to NR2E1, another NR expressed in the retina [12].
Smchd1 has a role in the expression of several autosomal gene clusters that are subject to monoallelic expression, rather than being restricted to functioning uniquely in X inactivation.
If the Bowtie alignment was restricted to only uniquely mapped reads (i.e. any read aligning to more than one region of the genome is discarded), there was a significant reduction in the number of aligned reads, with more than 96% of the total reads being discarded in the most severely affected sample.
Reassortment events leading to the generation of novel H5Nx subtypes are almost uniquely restricted to a single branch of the tree; the branch contains all isolates of the recent HPAI H5N2, H5N5, H5N6, and H5N8 outbreaks.
These results show that regulation of CTGF and TSP-1 by miR-18a and miR-19b is uniquely restricted to the cardiomyocyte.
Dedifferentiation of fully differentiated cells is not uniquely restricted to malignant cells, but upon damage or imbalance in tissue homeostasis, also normal mature cells can reprogram into a stem cell.
The similar histone modifications and replication timing profiles between ES and TS cells is consistent with mounting evidence indicating that only relatively few genes are uniquely restricted to the placenta, the vast majority of candidate TS-associated genes being involved in the development of other organs within the embryo proper [ 50].
Restricting ourselves to uniquely mapping piRNAs (to unambiguously identify the origin of each piRNA in the genome), we first scanned all 4,758 Ae. aegypti supercontigs individually using a 5 kb sliding window and identified those windows that had ten or more piRNA sequences mapping to them.
The lens rigidity problem we study is the following: Given M and D, do σ and ℓ, restricted to D, determine g uniquely, up to a pull back of a diffeomorphism that is identity on ∂ M ?
