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Since B-cell lymphomas are clonally restricted to express either kappa or lambda immunoglobulin light chain, we hypothesised that analysis of free light chain (FLC) ratios might facilitate the diagnosis of LM.
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But pictographic signs and logographic scripts with a limited readily learnable set of graphs are restricted to expressing a limited range of meanings.
In a subsequent series of experiments we confirmed that this reduction in cell surface IFNAR1 expression was restricted to cells expressing NS1 (Figure 3B).
While methylation may be capturing regulatory patterns established early in gestation or earlier shifts in cellular composition, the identification of differential expression is restricted to genes expressed perinatally.
This is underlined by experiments in mice indicating that SILV expression seems to be restricted to melanocytes expressing eumelanin [ 17].
To determine if the shadow marks on the female X chromosome are restricted to genes expressed in the soma, we examined male-biased expression in adult flies, which is dominated by expression within the male germline [ 2].
Strikingly, the ability of TGFβ1 expression to predict the poor outcome in breast cancer patients was restricted to TIF1γ expressing tumors.
Responsiveness to IL-11 is restricted to cells expressing IL-11Rα in addition to gp130.
These results suggest that insulin signaling defects in dmpk−/− mice are restricted to DMPK-expressing tissues.
However, the identification of distinct oxidases in whole cells is difficult and usually restricted to cells expressing only one type of oxidase.
This idea has been borne out by the analysis of mice bearing germline deletion of individual ERM proteins, where abnormalities are largely restricted to tissues expressing only one family member.
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