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This rather specific function is reflected in a limited expression profile of MMP-13 during development and adulthood, which is restricted to developing skeletal tissue.
The changes have not been restricted to developing countries (such as Brazil, which pioneered the development of bioenergy as a local energy solution).
However, unlike ATOH7 which is restricted to developing neuronal cells and is required for RGC development (6– 10), PAX6 is not only involved in mediating retinal progenitor cell fate (44) but also has a role in very early development in the migration of neural crest cells to form the lens placode (45, 46).
Such losses are not restricted to developing countries.
Pinchbeck also pointed out that the impact on coffee drinkers will be a useful reminder that climate change's impacts won't be restricted to developing countries.
The heterogeneity of medical training is not restricted to developing countries.
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Carmen Madrinan, the executive director of Ecpat International, a non-governmental organisation that combats the sexual exploitation of children, said the boom in internet paedophilia was not restricted to developed nations.
These are important factors as the issue of topical infections and bacterial resistance are by no means restricted to developed countries.
Obesity has become a global problem and is no longer restricted to developed countries.
Childhood overweight is not restricted to developed countries: a number of lower- and middle-income countries are struggling with the double burden of underweight and overweight.
Cost effectiveness analyses of the many interventions (primary prevention, screening or treatment) for reducing the burden of colorectal cancer have usually been restricted to developed country settings and with often considerable variation in the analytical methods used.
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