These results are in contrast with the current opinion that VHL mutations are exclusively restricted to clear-cell RCC.
The materials must be kept under lock and key, with access to them restricted to people cleared by government background checks.
The agency treats its recent successes in deciphering protected information as among its most closely guarded secrets, restricted to those cleared for a highly classified program code-named Bullrun, according to the documents, provided by Edward J. Snowden, the former N.S.A. contractor.
Most associations remained essentially unchanged when analyses were restricted to cases with clear cell histologic subtype.
Corticosteroid use was not restricted to patients with clear signs of inflammation, however – such as, for example, elevated ESR, myositis, or synovitis.
Diatom P values went from effectively 0.0 in comparisons of first hits to non-plastid-related genes, to effectively 1.0 when restricted to genes with clear similarity to oomycete homologs.
Further, our study of RCC is to our knowledge the first to evaluate associations with occupation and industry separately by race, and restricted to cases of clear cell histology.
Although we did not observe significant associations with RCC risk for the other a priori occupations or industries, there was a non-significant doubling of risk in the dry-cleaning industry, an association that strengthened when restricted to patients with clear cell RCC.
Notable studies regarding the environmental factors effecting aphid distribution in Kongsfjord (Svalbard archipelago) were carried out during the early 1990's [ 6, 20], concluding that the aphid was restricted to those areas which clear up from snow earlier in the season and where the aphid will experience the minimum number of degree days required to complete its annual life cycle [ 6].
Dryas octopetala, the host plant of A. svalbardicum, is a circumpolar evergreen mat forming dwarf shrub species typical from, although not restricted to, dry calcareous soils which clear up of snow early in the season [ 19, 45].
