This is of relevance, because it has been discussed that the different subunits of a G-protein subtype may not be restricted to activating only one signaling pathway [30].
Guo et al. suggest that the specificity of targets stems from their stable association with DNA: i.e., H2AX and Kap1 phosphorylation is restricted to ATM activated by DNA damage.
Activity of the S18A promoter appears to be restricted to meristems; plants activate an extra copy of this gene in tissues with cell division activity [ 31].
However, subsequent studies have indicated that the activity of erlotinib in second-/third-line settings is largely restricted to patients with activating EGFR mutations.
Also the localization of changes is restricted to the sensory pathway activated by the specific stimulus.
Thus in only a few cases was the upregulation of tested targets restricted to the cells expressing activated Notch.
Thus the ability to activate STAT1 appears restricted to the K650M and K650E-FGFR3 mutants, which however account for only a small minority of the FGFR3-related skeletal dysplasia cases.
To evaluate whether this enhancement was restricted to the TZM.bl cell line, activated PBMCs were treated with varying doses of Carraguard before being challenged with HIVBal or RT-SHIV.
In wild-type animals expression of neuronal precursor genes such as sens and ase is restricted to SOPs where they are activated by high levels of Ac and Sc [9], [10], [11].
Our studies indicate that the role of CD4+ T cells in modulating the CD8+ T cell response to the circumsporozoite protein of irradiated P. yoelii sporozoites appears to be restricted to ensuring the survival of activated T cells, without a discernible effect on the development of their functional properties.
Importantly, in non-tumor related tissues Plexin D1 expression is restricted to a subset of, presumably activated, fibroblasts and macrophages.
