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The cellular consolidation process is a time-restricted process, with amnestic agents being effective only during a restricted time window (McGaugh, 2000).
This mouse line utilizes the PTF1a promoter to delete the Robo3 gene specifically from the IO during a restricted time window in early development.
This indicates that with little loss of sensitivity, the restricted time window would be most appropriate to limit the number of generated signals.
This raises the possibility that a restricted time window exists following cortical insult during which specific rehabilitation strategies have optimal effects, as previously demonstrated following vestibular damage [38], [39].
Whereas for the 800 ms target duration, the distribution has the classical uni-modal and asymmetrical shape skewed toward long latencies, for all other tested durations a bi-modal distribution emerges as a consequence of missing responses within a restricted time window (corresponding to one or two bins of 25 ms).
Regardless, results indicate that char, in both cases, take advantage of the highly restricted time window suitable for upstream migration.
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To determine whether neurons carried significant texture or reward location signals during specific phases of the task, we divided the trials into three discrete phases (Touch: −1500 to −800 ms; Turn: −800 to 0 ms; Reward: 0 to 1000 ms) and followed the procedures given above for restricted time windows.
In conclusion, our findings demonstrate that: 1) mTOR-mediated mRNA translation is required for memory consolidation during at least two restricted time windows; 2) this kinase acts downstream BDNF in the hippocampus and; 3) it controls the increase of synaptic GluR1 necessary for memory consolidation.
Their concerns about our articles were restricted to "time window bias," known to others as bias due to differential exposure opportunity, which is an important potential bias that indeed should be controlled for.
This IP3 requirement restricts the time window of synaptic change to the time of IP3 activation, which varies across the PC-IN population.
Band pass filtering, by restricting the time window for temporal summation (Figure 5C), could sharpen coincidence detection in conjunction with a thresholding output synapse such as that made by rods [63], [64], and thereby help reject uncorrelated spontaneous photoisomerizations.
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