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As a planned sensitivity analysis, we restricted the screen items to two (Q1 & Q3), as it was possible that endorsement of screen item Q2 ('ever felt people were too interested in you') might be a direct result of having a severe chronic illness such as arthritis.
There was also some evidence of under-coding of epilepsy, because Ko increased to 0.35 when we restricted the screen to patients with multiple antiepileptic drugs.
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Since this was a pilot study, we restricted the screening to 5 patients.
So, for (first step) screening purposes one might restrict the screening to the five physical Fried criteria and not use a more elaborated (multidimensional) tool.
21 38 Furthermore, in countries where the allele frequency is low (about 1%), restricting the screening for this allele to a more high risk group of patients (for example, chronic renal failure) could also be a strategy for preventing SCARs.
In a planned sensitivity analysis where we restricted the DLE screen items to Q1 and Q3 only, the results remained essentially unchanged (data not shown).
We further restricted the cohort to 1756 screening attendees close to the age of 60, defined as being between the ages of 57.5 and 62.5 years at baseline.
The Production Code Administration, which had gone into effect just weeks after the release of The Thin Man and which restricted the drinking of alcohol on-screen, disapproved of the project even before a script was written.
These two disadvantages have restricted the use of forward genetic screens to a limited number of model organisms with a small body size and a short generation time, easy to rear and cross, and already equipped with established genetic tools for the fine mapping of mutations.
Prior investigation of the clinical manifestations related to telomerase deficiency has been restricted to the screening of patient cohorts with specific diagnoses (bone marrow failure, pulmonary fibrosis).
These analyses were restricted to the screening arm of the trial (n=77 445).
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CEO of Professional Science Editing for Scientists @ prosciediting.com