About two-third of non-small-cell lung cancer (NSCLC) patients are diagnosed with distant disease, which restricts the option of radically intended treatment to less than one-third of patients (Jensen et al, 2002).
As Prof. Julia D. Mahoney of the University of Virginia School of Law said, it is an "illusion" that preservationists "can save nature through calculated efforts to restrict the options of future generations".
Similarly, when you get married, you are deliberately restricting the options available to you; but that does not mean that it is irrational or unintelligent to get married.
Euro membership restricts the options, while the sheer size of bank debts and the past dependence of tax revenues on vanishing sources, such as rising property values, make pain inevitable.
Exchange controls would greatly restrict the options of the business class, who until now have used western banks and various offshore holdings to manage their Russian investments and to limit their exposure to political risks emanating from the Russian regime.
The implementation of the new rules on supervision and resolution, coupled with a long-lasting economic recession in the Eurozone, restrict the options available for dealing with the problems of the Italian banking system (and possibly, some German banks), and pose a significant threat for the stability of the banking system and, potentially, of the Eurozone itself.
This is the reason why many concepts are not mapped to existing ontologies, though also the lack of ontologies with a clear open license, as defined by the Open Definition [21], restrict the options.
Instead of outright totalitarian rule, you construct the appearance of democracy, while controlling it by subtly — in some cases perhaps not even consciously — restricting the options available to individual voters; by controlling a tiered system of "representative" electors behind the scenes; or by simply outright stuffing the ballot box.
This box is based on technology's necessity to restrict the options it programs into software.
Many of these bills are designed to severely restrict the options that women have for obtaining legal abortions.
It restricts the options for refusal to undergo immunisation or for postponement of immunisation available to beneficiaries.
