Sentence examples for restricted the expression of from inspiring English sources
Accordingly, in this physiologic experimental setting, with a ratio of FOXP3+ to FOXP3- cells of 1∶5 (i.e. mean 16.5% FOXP3+ cells vs. 83.5% FOXP3- cells before reactivation), it was even more apparent that FOXP3+ expression restricted the expression of IL2, but FOXP3+ cells could not actively suppress the expression of IL2 by most FOXP3- cells.
The system consists of a lentiviral vector carrying a dual-promoter system that allows specific induction and restricted the expression of genes in cardiomyocytes.
We restricted the expression of the human APP and BACE transgenes to the central nervous system of the fly by using the elav-Gal4 driver (Yao and White, 1994).
Interestingly, when we restricted the expression of the dominant negative insulin receptor to the developing eye using eyGAL4 (which produces a smaller eye under wild-type conditions), we observed a complete rescue of growth inhibition in the dfoxo Δ94 mutant background (Fig. 7D).
T cell-directed TGF-β restricted the expression of the high affinity IL-2Rα chain CD25 on early effector CD4 T cells in vitro and in vivo, while, early anti-viral effector cells generated in the absence of TGF-β signals displayed evidence of enhanced IL-2 signaling in vivo.
Hettinger argues that intellectual property "restricts methods of acquiring ideas (as do trade secrets), it restricts the use of ideas (as do patents), and it restricts the expression of ideas (as do copyrights)—restrictions undesirable for a number of reasons" (Hettinger 1989).
This approach exploits cellular gene regulatory elements that mediate cell type-specific transcription to restrict the expression of therapeutic genes or essential viral genes, ideally to cancer cells.
Recently, we were able to lower plasma homocysteine levels in mice with moderate hyperhomocysteinemia using an adenoviral construct designed to restrict the expression of DYRK1A, a serine/threonine kinase involved in methionine metabolism (and therefore homocysteine production), to hepatocytes.
In this line, the use of the rat insulin promoter 2 to drive the expression of CreER restricts the expression of the recombinase to pancreatic β-cells.
However, the regulatory mechanisms that restrict the expression of this gene in the germ cells is largely unknown at present.
In addition MET1 restricts the expression of imprinted genes in endosperm to the maternal alleles, resulting eventually in a different type of maternal control of endosperm growth.
