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Accordingly, in this physiologic experimental setting, with a ratio of FOXP3+ to FOXP3- cells of 1∶5 (i.e. mean 16.5% FOXP3+ cells vs. 83.5% FOXP3- cells before reactivation), it was even more apparent that FOXP3+ expression restricted the expression of IL2, but FOXP3+ cells could not actively suppress the expression of IL2 by most FOXP3- cells.
The system consists of a lentiviral vector carrying a dual-promoter system that allows specific induction and restricted the expression of genes in cardiomyocytes.
A 7-week losartan treatment downregulated tenascin-C and restricted the expression to the site of original tissue injury in the C7-hypomorphic forepaws (Fig 4A).
We restricted the expression of the human APP and BACE transgenes to the central nervous system of the fly by using the elav-Gal4 driver (Yao and White, 1994).
In both cases, we restricted the expression matrices to the 11 probesets and then applied regularized least squares in a leave-one-out cross validation loop, estimating the corresponding generalization error (see Table 3).
For each dataset, we restricted the expression matrix to a submatrix of the 11 variables of the inferred signature and we estimated the generalization error of a Regularized Least Squares classifier in a leave-one-out cross-validation loop.
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This approach exploits cellular gene regulatory elements that mediate cell type-specific transcription to restrict the expression of therapeutic genes or essential viral genes, ideally to cancer cells.
Recently, we were able to lower plasma homocysteine levels in mice with moderate hyperhomocysteinemia using an adenoviral construct designed to restrict the expression of DYRK1A, a serine/threonine kinase involved in methionine metabolism (and therefore homocysteine production), to hepatocytes.
The "clawback" provisions in article 10(2) therefore play a very important role in allowing the authorities, and the courts, to restrict the expression of thoughts, which, if brought into effect, would undermine the very basis on which common law and Convention rights exist.
Mesp2 also induced the expression of Ripply 1 and 2, which in turn played roles in restricting the expression domain of Mesp2 by suppressing the activity of Tbx6.
However, the regulatory mechanisms that restrict the expression of this gene in the germ cells is largely unknown at present.
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