Nevertheless, neurotrophins themselves share poor pharmacokinetic profiles, mainly because of their sensitivity to proteolysis, restricted penetration of the blood brain barrier, and limited ability to diffuse in tissues, factors that all hamper their use as drugs.
Factors that have been considered to be responsible for the increased resistance to antibiotics in bacterial biofilms include restricted penetration of antimicrobials caused by the exopolymeric material (EP) (14 ).
Furthermore, CHG, as with other antiseptic preparations exhibits restricted penetration through the skin; our previous studies demonstrate that CHG from aqueous and alcoholic [70% (v/v) isopropyl alcohol (IPA)] solutions poorly penetrate the full thickness skin to the deeper skin layers [ 2, 3].
Nevertheless, the idea has yet to become a reality as it continues to struggle with a number of issues such as (i) the lack of enforcement strategy; and (ii) issues related to the veracity and reliability of the information, as well as restricted penetration of the ATIS.
Nikaido and Rosenberg [43] showed much restricted penetration of antibiotic molecules with bulky side-chains and negative charges through OmpC than through the wider OmpF channel.
Before undertaking this study, we were concerned that CSF infection might not respond as well as systemic infection to treatment because of restricted penetration of many antiretroviral drugs [ 10].
