Smad8 is initially expressed only in the visceral yolk sac (VYS) endoderm and shows a highly restricted pattern of expression in the embryo proper at later stages.
It is likely that as more miRNAs are characterized, many will have a tissue or developmentally restricted pattern of expression.
The highly restricted pattern of central innervation of GFP-positive RGC axons at P10 was essentially same between the heterozygous and homozygous mice (data not shown).
These mutations might be at diverse loci, but they all finally led to a "convergent developmental feature", i.e. a restricted pattern of RhAG expression leading to double flower formation.
In contrast, there was a remarkably restricted pattern of MET expression in the macaque neocortex at GD100 and GD150.
For MBNL1, it exhibited a regionally restricted pattern of expression in canal region endocardium and ventricular myocardium during endocardial cushion development in chicken (Vajda et al., 2009).
However, none of the BIPs identified thus far show a tissue restricted pattern of expression that could explain the tissue tropism of brca1-related cancers.
GD2 is a cell-surface molecule with a highly restricted pattern of expression and therefore amenable to targeting by monoclonal antibodies (mAbs) and their derivatives.
Despite substantial uncertainty regarding the ecologic parameters of the transmission cycle, our results suggest that YFV has a highly restricted pattern of geographic distribution within Peru.
In contrast, pronounced Bmp4 expression was detected throughout the entire lung mesenchyme at E11.5, compared to the relatively restricted pattern of Bmp4 expression to the tips of epithelial cells in WT lung (Fig. 9c).
For example, IFNγ can induce TNFα and NOS2, and has differential effects on several individual chemokine genes [ 8] that provide for selective stimulus sensitivity in mediating restricted pattern of chemokine gene expression.
