Sentence examples for restricted nature of from inspiring English sources
Fusion of m36 to human IgG1 Fc resulted in dramatically diminished neutralization potency most likely due to the sterically restricted nature of the m36 epitope that limits access of large molecules.
"In fact, given the tightly restricted nature of our immigration system today, for many of these individuals it is probably the only possibility for them to come lawfully to the U.S".
This knowledge gap, and the human restricted nature of these bacteria, limit our understanding of the disease and impede the development of new diagnostic approaches.
Because of the highly restricted nature of its cellular targets (i.e. B cells), specific BLyS antagonists have an excellent chance of not promoting multiple global toxicities.
The absence of a sensorimotor phenotype in these mice is obviously not surprising in view of the spatially restricted nature of the mutation, but highlights the advantage of this more selective approach.
The taxonomically restricted nature of the Laurentian fauna may be due to a limited influx of early colonists from Gondwana, whereas other eurypterid groups arrived in the early Silurian.
Thus, the myeloid-restricted nature of CEBPE precludes the expression of RETN in human adipocytes which, however, are targeted by this innate immune-derived proinflammatory cytokine.
The CD1d-restricted nature of NKT lymphocyte activation was confirmed by partial to complete inhibition of cytokine secretion and proliferation in the presence of anti-CD1d blocking antibody (Figure 6).
The tissue-restricted nature of this phenotype indicates the presence of overlapping and partially redundant roles for other E2F transcription factors [1], [2], [4], [18], [19], [20]; for instance, it is known that E2F5 and E2F6 can compensate for loss of E2F4 [22], [22].
Assessment of paratyphoid vaccine efficacy in preclinical studies is complicated by the lack of a small animal model and the human-restricted nature of the infection.
However, not all features of NS and LS are recapitulated in these mouse models, in part owing to the tissue-restricted nature of SHP-2 deletion.
