Sentence examples for restricted lifespan from inspiring English sources

Mesenchymal stromal cells have a restricted lifespan in vitro such as any other somatic cell and can therefore only be expanded for a limited number of cell divisions before entering a senescent state and unequivocally stopping proliferation.

As indicated for pancreatic [ 17], renal [ 43], hepatic [ 16, 44], reproductive tract [ 28, 29] and central nervous system [ 30, 44- 48] responses to dysregulated db/db-syndrome microenvironments, diabetes-affected cellular differentiation, proliferation and maturation indices are compromised, resulting in growth abnormalities and restricted lifespan expectancies [ 16, 18, 30, 49].

Insulin signaling restricts lifespan and stress resistance mainly by inhibiting nuclear localization of the conserved FOXO transcription factor DAF-16 (Henderson & Johnson, 2001).

In the developed world, malnutrition and infectious diseases no longer restrict lifespan resulting in a shift in the demographics with increasing populations of elderly people and increasing prevalence of age-associated disorders.

The experimental design was based on the assumptions that (i) genes that are differentially regulated in human cellular aging and senescence are trustworthy candidates for modulators of aging and that (ii) the ability of a certain gene to restrict lifespan in yeast suggests that this gene has a role in modulating the rate of aging that potentially extends beyond yeast.

Primary ECs, however, have a restricted proliferative lifespan which hampers their use in long-term studies.

Disruption of telomerase activity in human normal cells slows cell proliferation, restricts cell lifespan, and changes the maintenance of the 3' single-stranded telomeric overhang without changing the rate of overall telomere shortening [25], [26], [62].

Most somatic cells are reported to express low levels of hTERT protein [27] [30] and disruption of the activity in normal cells slows cell proliferation, restricts cell lifespan, and alters the maintenance of the 3'-single stranded telomeric overhang without changing the rate of overall telomere shortening [25], [26].

This gene encodes a protein that is known to restrict the lifespan of yeast cells.

It remains to be formally demonstrated which DILPs are restricting normal lifespan and we have not established a biochemical link between the increase in DILP2 protein and an increase in IIS.

Hence, apoptosis of mature DCs by FasL-expressing activated antigenic T cells restricts their lifespan and thereby limits the duration of an immune response through a negative regulatory loop.