To ascertain whether involvement of HMOX-1 in bortezomib-induced cell death is not restricted in TaY cells, we analysed the effect of CoPP in MT-2 and MT-4.
These results, combined with the in vivo binding data, indicate that Ttk69 acts as a potent repressor during mesoderm development, being required to restrict enhancer activity in cells of both the somatic and visceral mesoderm, as well as in other embryonic tissues.
Thereby caspase-3 is activated to the maximally possible amount in the model which is restricted in wildtype cells by the presence of XIAP.
Histological sections showed that ScFgf8, ScShh and ScBmp4 were only expressed in the inner dental epithelium during the ED stage, with ScShh and ScFgf8 transcripts restricted in few cells at the tip of the developing central cusp and ScShh being expressed in a broader area than ScFgf8 (Fig. 4j1, l1 and n1).
Previously, it was reported that the Flt-4 expression was restricted in the endothelial cells of lymphatic vessels.
Since PPARγ is the key regulator of adipogenic differentiation, its transcription is highly restricted in most of cell types [ 4].
A picture has emerged in which a small number of self-renewing stem cells give rise to multipotent progenitor cells, from which successive generations of progenitor cells can develop, each progressively more restricted in the types of cell they can develop into.
Furthermore, we found that HIV-1 produced in the presence of high levels of Mov10 is restricted in infection of target cells either prior to or at the initiation of reverse transcription.
It is possible that such generation of oxidative stress is restricted in terms of relevant cell types, and thus the transcriptomic signal was too dilute in our whole-organism extraction to be detected.
In contrast, stimulation with complex TLR9 ligands is more restricted in terms of responding cell types and, in DCs, proceeds through early endosomes instead.
