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The functional changes induced by BPA and MP closely parallel known outcomes of mTOR pathway activation (26) and tumor behavior (29) and reveal an underlying mechanistic basis for restricted effectiveness of breast cancer treatment and prevention strategies.
There were many factors which contributed to the restricted effectiveness of interventions: small sample size, small power to detect differences between groups, baseline differences between groups, the intensity levels of interventions, lack of wait-list control group by comparing the intervention group results with another intervention type or minimal intervention, and adherence.
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Without a banking union, cross-border capital flows can be restricted, the effectiveness of monetary policy impaired and, in the extreme, the viability of the union itself undermined.
However, the complexities inherent in large ER diagrams have restricted the effectiveness of their use in practice.
Gerrard has been plagued by the problem for several years now and it restricted his effectiveness in the last campaign, when he played only 21 of 38 Premier League matches.
However, the use of a surgical microscope has restricted the effectiveness of the surgical navigation because it has been difficult to deliver the navigational information to the surgeon from outside of the surgeon's visual attention.
If Terrell Suggs and Elvis Dumervil can get pressure on the quarterback on Sunday, they might be able to restrict the effectiveness of the Packers' downfield passing game.
Plenty of good teachers favour school choice, knowing it would free them from union rules that restrict their effectiveness.
For the near-CS group, anthropogenic pollution adds ions to the groundwater restricting the effectiveness of the ternary EMMA approach.
Note, that the USRP front-end introduces several nonlinearities that restrict the effectiveness of the OOB reduction to approximately -45 dB.
There could also be issues around service delivery (such as service provider attitudes, unofficial payments) that restrict the effectiveness of these initiatives.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com