Current guidelines suggest imaging in the presence of symptoms only, for example, bone pain or fracture11, thus, restricting diagnosis to patients with debilitating or complicating metastases.
By restricting diagnosis to CDC two-tier serologic reporting criteria, a greater truth may be missed in that diagnoses of such patients with non-Lyme borrelial infections would not be possible in the absence of species-specific testing for the new species, which is largely unavailable.
Additionally, limiting analysis to recombinant major allergens potentially restricts diagnosis to just over half of the affected population [39] and due to the lack of post-translational modifications, some recombinant allergens may not display the same immunological reactivity as their native counterparts [40].
Our data support the conclusion that B7-H1 expression upon AML at diagnosis is restricted; upon diagnosis, only 18% of patients expressed B7-H1 in most cells.
Some authors have included urticaria-associated angioedema in this category, while others have restricted the diagnosis of IAE to patients with recurrent angioedema without urticaria [10].
These analyses were restricted to diagnosis years 1990 to 1999 so that patients would have the opportunity for five years of follow-up (most follow-up ended in 2004).
In contrast, early formulations of PTSD restricted the diagnosis to survivors of extreme events such as torture, political persecution and sexual assault [ 4].
Recruiting doctors' involvement was restricted to diagnosis followed by determining the patients' interest in participating, excluding patients who were not eligible and a telephone referral to the on-call otolaryngology doctor.
The INSS criteria for stage 4s NB are similar to those of the original Evans' classification, but restrict this diagnosis to children of less than 1 year at diagnosis and with less than 10% of bone marrow involvement (Brodeur et al, 1993).
So to restrict clinical diagnosis to those patients who have the several objective features included in the CDC reporting criteria would mean that a great many patients would go undiagnosed.
41 A study examining both depression and anxiety disorders before PD found that the increased risk of PD seen after depression was attenuated when restricting depression diagnosis to more than 5 years in the past.
