Sentence examples for restricted by different from inspiring English sources

We also investigated the interactions between CTL responses restricted by different HLA alleles in overlapping and flanking epitopes in the p17 region of HIV-Gag and HIV-Nef.

However, interpretation of these data is restricted by different directions of the DAT effect.

Commensurate with this, APL used by LCMV to escape host defenses will have a different effect on the T cells that are restricted by different MHC types.

First, since CD4+ and CD8+ T cells are restricted by different MHC families, it is desirable that DC process antigen to enable presentation of derived epitopes both by MHC class I and II.

Interestingly these T-cell clones use different T-cell receptors and are restricted by different HLA class II molecules, indicating that this is a general, rather than anecdotal finding.

γδ T cells specific to the same antigen but restricted by different CD1 may be recruited in vivo to different anatomical sites depending on the distribution of CD1+ APC [ 13, 19, 20].

Remarkably, some immunodominant epitopes were cross-restricted by different HLA proteins in different patients.

To pursue this line of investigation, we analyzed PD-1 expression at a given time point in an individual with CD8+ T-cell responses directed against five different epitopes derived from four different HIV-1 prestrictedstricted by two different HLA-B molecules (Fig. 3 a).

Six different CD8+ T-cell epitopes restricted by five different class I MHC haplotypes have been identified in the Tp2 protein (Fig. 4).

Disregarding the six cryptic restrictions mentioned above including the nested peptide restrictions, we suggest that the 26 identified WNV CTL epitopes are restricted by 11 different HLA class I alleles (A*0101, A*0201, A*0301, B*0702, B*0801, B*2702, B*4001, B*4403, B*5601, Cw*0304, Cw*0602) covering 7 of the 12 major HLA-A and HLA-B supertypes.

The protein 392 amino acids in length contains about eighty CTL-epitopes, many of which are overlapping and are totally restricted by ten different HLA class I molecules.