Possible masking/de-masking of SDRs by using restricted backgrounds for the PRR calculations was evaluated by comparing true-positive SDRs, the "A s, in the respective models.
Results from the most restricted backgrounds, the drug classes, were not satisfying for signal detection purposes, as their ability to detect true-positive SDRs was poor; this also confirmed the inherent feature of all signal detection methods in that the lack of detection of an SDR does not imply a lack of a causal relationship between a drug and a reported ADR.
To further restrict background transcription, we also introduced a Lac repressor protein based roadblock to transcription elongation.
We performed ENMs using locality data of A. femoralis from eastern Australia and of A. femoralis from Western Australia, restricting background data to areas likely to be colonizable for the species as recommended by Phillips et al. [87] Therefore, we manually delimited areas encompassing the known localities, separating them from completely arid areas away from the coast (Fig. S1).
Using these approaches, we show that patients with MDR TB in the Eastern Cape could be divided into 2 distinct groups: isolates from patients infected with MDR ss showed diverse genetic backgrounds, while isolates from patients infected with pre-XDR TB and XDR TB showed restricted genetic backgrounds.
The novel method investigated, hereafter called PRR-by-therapeutic area (PRR-TA), uses logically restricted comparator backgrounds for the PRR calculations in drugs for common therapeutic areas.
In Renaissance painting, genre subjects were generally restricted to background features of portraits and historical narratives.
I refuse to be restricted by background or fear.' Which is, of course, one of the messages of Battleship Potemkin.
Finally, variables on the individual level were restricted to background variables.
Staining in non-neurological controls was largely restricted to background extracellular immunolabelling, except for antibodies against C3b, clusterin, fH-Tyr402 and C1inhibitor (C1inh) which significantly stained cells in some controls.
"Affordability is absolutely a key part of what we are here to do," says Gillies. "In our view, to charge a £9,000 fee for a large number of our courses would be really restricting the backgrounds of students".
