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The first study of KMC in preterm neonates, with restricted age of 32 36 weeks gestational age, had significant decreases in scores of a multidimensional scale that also included behavioral and physiological components [ 34].
Whilst older age was significantly associated with survival following NADC diagnosis in univariate analyses, it did not remain significantly associated with survival in adjusted analyses; this may reflect the relatively restricted age of the underlying cohort population, and of cohort participants at the time of NADC diagnosis.
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However, similar findings were obtained after we corrected for these differences by regression analyses for IgG titers and by selection of more restricted age groups for the frequency analysis of PCs and Bmems.
Our smaller sample size, restricted age range, and definition of physical activity may explain our divergent finding, although further examination of this relationship with a larger sample size is required.
For example, not all studies restricted age groups to cohorts of five years.
Seven of the studies (23 %) (2 from the same paper) were conducted in a restricted age population (age range of 30 years or less) [ 6, 13, 30, 36, 40, 43] and three of the studies were conducted in women only (2 from the same paper) [ 31, 43] (Tables 1 and 2).
First, the moderate response rates, restricted age range and the lack of participants from rural areas affect the generalizability of the results to national trends.
Higher consultation rates and restricted age bands reduced the performance of the Charlson index, but the index's excellent performance persisted over longer follow-up; the C statistic was 0.87 over 1 year, and 0.85 over all 5 years of follow-up.
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We did not strictly match cases and controls by age; however knowing that the majority of cases were children under one year of age we restricted the age of controls to 24 months or less.
When we restricted the age of diagnosis from 0 to 14 years of age, we observed an overall SIR of 1.10 (95% confidence interval (CI); 0.58 1.88).
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