Sentence examples for restricted affinity from inspiring English sources

Recent trials of a HLA-A01 restricted, affinity enhanced MAGE-A3-specific TCR uncovered serious toxicity with unexpected recognition of titin, a cardiac petide antigen in subjects being treated for melanoma and myeloma (Cameron et al, 2013; Linette et al, 2013).

Moreover, mitochondria derived from these same cells could be induced to release cytochrome c following exposure to enabler BH3 peptides with restricted affinity for only a subset of Bcl-2 proteins, such as NoxaBH3 for Mcl1 (as with IMR5, Figure 1) suggesting a "primed for death" status consistent with the direct-activator model.

The repertoire of 'natural IgA' is restricted and affinity maturation is limited, although the heavy-chain variable region genes used by IgA-producing plasma cells in the gut are somatically hyper-mutated, to diversify antibody specificity [ 42].

In fact, the protein's structure and biochemical properties suggest the importance of simultaneous regulation by several interaction partners to restrict high affinity interactions to adhesion sites [17], [18].

These values are the closest estimation of the properties of the protein-protein interaction, because proteins remain solubilized and unconstrained while titrated in their native state, unlike other techniques based on immobilization that change or restrict the affinity.

In the case of Nkx2.2, decreasing the affinity restricted Nkx2.2 expression more ventrally (Fig. 4D,J,K), whereas increasing the affinity expanded its expression dorsally (Fig. 4E,L,M).

Firstly, they possess punctate spores, which as mentioned earlier restricts their affinities to the red algae and fungi.

For CLAMP, we found indications of a close proximity with MSL3, but in contrast to the proposed interaction being restricted to high-affinity sites, we detected signals all along the X chromosome, reproducing the normal targeting of the MSL complex.

However, comparison of the in situ PLA signals to the observed binding patterns of MSL components at high-affinity sites visualized by expression of MSL2 in msl3 mutant females (w; P[w + hsp83:msl2] msl3/ TM6B) indicated that the interaction is not restricted to high-affinity sites as proposed, but rather extends to all binding sites of the MSL complex on the male X chromosome (Fig.  6).

Since this transcription factor controls the expression of the high-affinity transporter PaCTR3, copper uptake in the mutant is restricted to a low affinity uptake system and results in cellular copper depletion [10], [18], [19].

The AP forms complexes with an array of 1,25(OH)2D3 molecule conformations, while the GP is more restricted with its binding affinity.