Also, AKs on the scalp are generally thicker than those seen on the face, which may restrict absorption of ingenol mebutate on the scalp.
If restricted to absorption lines it would look similar to the illustration (top right).
Most anticancer drugs are water-insoluble, and the poor solubility seriously restricts their absorption.
The most common is iron deficiency anemia from chronic blood loss, reduced dietary intake, and persistent inflammation leading to increased hepcidin levels, restricting iron absorption in the duodenum.
The xenobiotic transporters, Multidrug Resistance 1 (MDR1/andBreast Cancer Resistance Protein Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH).
The 2 1 reaction stoichiometry restricts CO2 absorption capacity of primary and secondary amines to a theoretical upper limit of 0.5 mol CO2/mol amine.
Macrolide antibiotics like AZM and Clarithromycin (CLR) are large molecular weight compounds and are substrates for apically polarized efflux transporters such as P-glycoprotein, which can potentially restrict intestinal absorption.
Crucially, however, none of these studies has considered the role of silica, the principal defence in grasses (Massey et al. 2007 a ), which our previous work has found to reduce foliage digestibility severely for voles by restricting nitrogen absorption from grass leaves (Massey & Hartley 2006).
