On the other hand, under pathological conditions, the perivascular end-feet can restrict transport or diffusion across the blood-brain interface [ 31].
Social exclusion arising from transport exclusion and the web of complex relationships between exclusion of various types is, then, a major challenge to wellbeing as people move through the lifecourse, when disability, financial barriers or lack of accessibility potentially restrict transport availability and choice (Church, Frost and Sullivan 2000; Rye and Mykura 2009; Social Exclusion Unit 2003).
Additional constraints were applied to the fumarate and succinate inner mitochondrial membrane transport steps to represent restricted transport (especially for fumarate, as a specific mammalian fumarate transporter has not been identified).
There is significant evidence across countries that lower-income populations tend to suffer more from restricted transport options, have lower quality transport services available to them and travel under worse conditions (safety, security, reliability, comfort).
11) states in clear and certain terms: There is significant evidence across countries that lower-income populations tend to suffer more from restricted transport options, have lower quality transport services available to them and travel under worse conditions (safety, security, reliability, comfort).
Under normal conditions, the intestinal epithelium acts as a protective barrier restricting transport of luminal antigens, and only allows small and selective quantities to permeate the mucosa [16] [18].
A primary function of the endothelium is to serve as a permeability barrier that restricts transport of macromolecules such as insulin into the interstitial space.
A number of barriers were identified such as access difficulties associated with increased age, limited mobility and restricted transport options, as well as financial constraints.
Due to its protective function the BBB restricts transport of substances into the brain via both the physical (tight junctions) and the metabolic (enzyme) barriers [ 32, 33].
The physical environment in endemic areas, such as Warrap and Lakes states, largely consists of seasonal swamps, restricting transport of supplies and making transport, when possible, slow and expensive.
The Dartford Crossing is class C, which restricts transporting goods such as nitrates and flammable liquids.
