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Since many enhancers tend to be cell-type specific, high nucleosome occupancy of TFBS can restrict their utilization to a certain cell type.
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Apart from this, the cohesin dockerin interactions are species specific, which restricts their utilization over a narrow range.
This problem has restricted their utilization in commercial or industrial applications and resulted in extensive research efforts on improving resistance against various types of wear damage.
However, rapid emergence of drug-resistant mutants restricts their utilization 3, 4, and therefore leads to an urgent need to develop novel antivirals.
And no one has restricted their use.
However, the high cost of these tubes restricts their use.
But these methods are not easily extended to other level set methods based on partial differential equations [39], and sometimes with the boundary leakage problems, which extremely restrict their extension and utilization on the image segmentation.
Anorexics severely restrict their calories.
However, low generation power and large thickness restrict their usages.
However, partial antagonism and limited potencies restrict their versatility.
Let your characters restrict their own movements.
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