Sentence examples for restrict the expression from inspiring English sources
This approach exploits cellular gene regulatory elements that mediate cell type-specific transcription to restrict the expression of therapeutic genes or essential viral genes, ideally to cancer cells.
Recently, we were able to lower plasma homocysteine levels in mice with moderate hyperhomocysteinemia using an adenoviral construct designed to restrict the expression of DYRK1A, a serine/threonine kinase involved in methionine metabolism (and therefore homocysteine production), to hepatocytes.
However, the regulatory mechanisms that restrict the expression of this gene in the germ cells is largely unknown at present.
Negative feedback on TOR pathway function to restrict the expression of FLO11 under nitrogen starved condition and also with re-addition of nitrogen to starved cells.
This analysis indicated that the drop in the expression of FLO11 depended on the first term of Equation 4, which essentially functions as a mechanism to restrict the expression of FLO11 under starvation.
Evidences showed that cAMP-PKA, MAPK and TOR pathways function in parallel to regulate the expression of FLO11, where loss of function in either of these pathways was sufficient to restrict the expression of FLO11[8], [9], [44].
Mesp2 also induced the expression of Ripply 1 and 2, which in turn played roles in restricting the expression domain of Mesp2 by suppressing the activity of Tbx6.
In this line, the use of the rat insulin promoter 2 to drive the expression of CreER restricts the expression of the recombinase to pancreatic β-cells.
In addition MET1 restricts the expression of imprinted genes in endosperm to the maternal alleles, resulting eventually in a different type of maternal control of endosperm growth.
As numerous metazoan elements display expression that is restricted to the reproductive apparatus, including the germ line and in surrounding somatic tissues, genomes have evolved specific mechanisms to protect these tissues by further restricting the expression of these elements.
The transcription factor TFII-I (Table 1) restricts the expression of β-globin to the adult stage of erythropoiesis thus maintaining the primitive phenotype of murine embryonic stem cells [41].
