Sentence examples for restrict the developmental from inspiring English sources
In summary, we illustrate how mild, maternal PEM experienced during early gestation can significantly restrict the developmental potential of the fetal kidney and highlight a nutritional pathway that may underpin this effect.
These experiments show that NuRD activity and DNA methylation function in a non-redundant manner to restrict the developmental potential of pluripotent cells, effectively constructing a barrier between ES cell and TS cell fates.
In the report by Sivaraman et al.[ 7], the authors propose a cell-fate model in which pregnancy hormones restrict the developmental fate of a subset of mammary epithelial cells causing permanent changes in their responses to carcinogen stress, and therefore making them resistant to tumorigenesis.
Erm functions together with BAP and HDAC3 chromatin remodeling complexes after Brat and Numb to further restrict the developmental potential of INPs by attenuating the response of INPs to self-renewal factors such as Klu and Dpn (Janssens et al., 2014; Koe et al., 2014).
Pax5 is the decisive B lineage commitment factor that restricts the developmental options of early progenitors to the B cell pathway [25].
In Drosophila, F ezf2 restricts the developmental potential of intermediate neural progenitors (Weng et al., 2010).
Moreover, paraxial and lateral mesoderm contribution was highly enriched in CHI-treated EpiSCs and axial mesoderm was not colonised at all (Fig. 5E), suggesting that high Wnt activity restricts the developmental potential of mesoderm progenitors.
Recent evidence indicates that this phenomenon is due to cell cycle-dependent mechanisms that restrict the initial activation of developmental genes to the G1 phase.
It was further discovered by Höckel and coworkers that cervical carcinoma growth is restricted to the developmental compartment for tumor progression.
This suggests that other (e.g. developmental) constraints may restrict the number of adjacent neurons.
Recent studies in Drosophila have identified several regulatory proteins that prevent this developmental reversal and restrict the proliferation of intermediate neural progenitors.
