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It is important to restrict transfusions to limit morbidity and mortality and to make efficient use of RBCs [ 4].
Despite these beneficial properties, major shortcomings such as their limited supply and donor-site morbidity restrict their use in clinical practice [ 1– 3].
Moreover, adverse effects and complications with some of these interventions (medication and surgery) and the presence of co-morbidities commonly restrict their use.
This will be harder to achieve in larger UK trials with long follow-up, in which many patients will have developed co-morbidities that restrict their ability to attend the outpatient clinic, have moved away or died of unknown causes.
Frailty can range from mild to severe stages, and it is regarded as being strongly linked to restricted activity and morbidity.
Medications and co-morbidities are two such factors that often restrict patient selection and complicate data interpretation.
The survival rate of early PRIS was 95.5%, and morbidity was restricted to four patients.
Others have found the relationship with smoking was restricted to increasing asthma morbidity [ 10, 11].
Indeed, in the former case the purpose is to maximize the coding of complications and co-morbidities (e.g., CCI), while in the latter it is to restrict it to conditions really affecting care [ 32].
Our patients may therefore be more representative of patient populations as seen by treating physicians in outpatient clinics, as our patient selection did not restrict on etiology of the primary kidney disease, level of eGFR or severity of co-morbidities.
These diseases cause morbidity and then death when untreated in humans (1) and significantly contribute to poverty and restrict economic development in afflicted regions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com