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Women are hit by more physical restrictions than men and suffer more often from multimorbidity and non-fatal illnesses which restrict functional health [26].
PNNs appear at the end of the critical period for plasticity and persist in adulthood where they restrict functional plasticity of mature neuronal circuits (Kwok et al. 2011).
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Postural instability restricts functional performance and upper extremity function in children with CP [ 21].
MEG high temporal resolution allows to detect relatively restricted functional neuronal pools activated during cerebral processing of external stimuli.
Davies (2001) argues that the first of these claims can be defeated by restricting functional ascriptions to hierarchically organized systems in which lower level capacities realize upper level ones.
Our results show that while in subjects with LTBI there was a high percentage of IL-2+/IFN-γ+ and IL-2−/IFN-γ+ peptide-specific CD8 T-cells, the IL-2+/IFN-γ+ population was consistently reduced in TB patients, highly suggestive of a restricted functional profile of Mtb-specific CD8 T-cells during active disease.
CD8 T-cells from subjects with latent infection showed a codominance of IL-2+/IFN-γ+ and IL-2−/IFN-γ+ T-cell populations; interestingly, only the IL-2+/IFN-γ+ population was reduced or absent in tuberculous patients, highly suggestive of a restricted functional profile of Mycobacterium tuberculosis-specific CD8 T-cells during active disease.
However, the small number of GO annotated sequences restricted functional annotation of our libraries.
They show restricted functional ability [ 7] and frequently receive a disability pension [ 8].
This furthers restricts functional access to services in the community given cultural barriers to women receiving care from men.
In addition to restricting functional data, our transcriptome data can also be used to expand functional regulatory networks from RNAi screens.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com