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Rather than trying to use cutting-edge advanced meta-analysis methodology, in a sparse data context, it may often be wiser to restrict focus to simpler methods (e.g. fixed effect models) and be realistic about the potentially limited conclusions that can be drawn from the data.
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Dutton draws on a 2005 study that compared the profiles of business leaders with those of hospitalised criminals to reveal that a number of psychopathic attributes were arguably more common in the boardroom than the padded cell: notably superficial charm, egocentricity, independence and restricted focus.
For susceptibility values below the weakly susceptible regime, the model predicts spatio-temporal SD pattern that do not break away from an initially restricted focus.
Other similar expressions exist albeit with a sometimes slightly restricted focus.
However, restricting focus to established clinical criteria is not a viable option when the primary goal is the discovery of potentially novel mechanisms.
200 bp is a commonly used cut-off for defining likely operons [ 40, 41], and restricting focus membership to genes within an operon is a desirable outcome.
1d) The restricted focus on NRPS and KS pathways, which in turn select for a subset of bacteria (with an explicit reference to the recent Fischbach paper in Cell).
To increase power to detect differentially methylated CpG sites, we completed a meta-analysis of results from three DNAm experiments using two genome-wide methylation arrays, restricting focus to high quality probes on both arrays.
In scoring the SLIM phenotype, reduced and restricted foci on leaves was considered to be the primary phenotype whereas leaves with foci on or in contact with the midrib or at the edge of the leaves were not scored.
However, the MP-related attenuation of CBF increases by the task in these studies was much more restricted (focused to discrete brain regions) than the large and extensive attenuation in whole brain metabolism we report using [18F]FDG.
In addition, activity was found in bilateral regions of the frontal cortex, which probably relate to the frontal eye fields [27 −9 51; −24 −6 60], as well as restricted foci about the central sulcus [right post-central gyrus (r GPoC) and left pre-central gyrus (l GPrC); 48 −30 39; −5483 33].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com