It is intriguing to speculate that these endogenous Na+,K+-ATPase inhibitors allow animals to maintain proper physiological levels of autophagy by restraining excessive levels that may maladaptively promote autosis.
The induction of autophagy in response to loss of TIGAR can function to moderate apoptotic response by restraining ROS levels.
In contrast, we readily detected Lys-382 acetylation on stabilized p53 in these cells, indicating that CHD4 is needed for restraining basal levels of p53 acetylation.
I may sound like a crazy superfan bordering on restraining order-level enthusiasm, but I can't help it.
Restraining the level of abstraction to outcomes that are conceptually closer to clinical parameters and the surgical intervention, such as symptoms and functional status domains [ 5], may prevent misunderstandings and facilitate joint decision-making between patient and provider.
Taken together, analyses of gene expression at the single-cell level indicate that the increase in steady state mRNA levels detected by quantitative RT-PCR in Mbd3 −/− ESCs is due to the failure to restrain transcription levels of actively transcribed genes irrespective of culture conditions, as well as a failure of gene silencing in a subpopulation of cells grown in serum and LIF conditions.
Animal experiments suggest that the mechanism of AHP may be related to reducing serum IgE and IL-4 levels, restraining the release of inflammatory mediators, and adjusting the expression level of transcription factors in the rat model of asthma [ 7, 8].
Our findings suggest that restraining the physiologic levels of AID expression can be a mechanism that allows the achievement of an optimal balance between immune proficiency and genome integrity.
Downing Street said it had no plans to urge other RBS board members to restrain the level of their bonuses, saying the bank's management was doing a good job.
In our simulations, as in previous studies of recurrent microcircuits (Douglas et al. 1995), background forward inhibition was sufficient to restrain the level of activity in microcircuits that included up to 150 cells.
