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The observation further indicated that TP5 restrained the binding of mAb-DR to HLA-DR molecules.
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Thirdly, a directly interaction between MdERF2 and MdERF3 restrain the binding of MdERF3 to the MdACS promoter, and then suppress the MdACS expressed in fruit flesh (Li et al. 2016).
The spatial occupancy maps of the ligand computed from the 100 RAMD simulation trajectories indicated that the receptor ligand interactions that restrained the ligand in the binding pocket were the major resistance encountered by the ligand during exit and no second barrier was notable.
The conformational change restrains the vacant binding site such that its affinity for binding the second ligand is reduced.
Comparison of the refined structures of full-length toxin, which lacks ADP-ribosyl transferase activity, to that of the enzymatic domain alone reveals a salt bridge between Arg467 of the catalytic domain and Glu348 of domain II that restrains the substrate binding cleft in a conformation that precludes NAD+ binding.
Other passengers restrained the man.
Of particular significance, p53 restrained the SASP [ 22].
Here RE represents the solvated complex of the E2 and receptor, and
HDL binding restrains the overall motion of the active site and particularly of N168, thus reducing the catalytic activation energy barrier.
In rhizavidin, a disulfide bridge connecting the L3,4 and L5,6 loops restrains the L3,4 loop conformation, leaving the binding-site residues essentially unchanged upon biotin binding.
This is typically achieved either with non-equilibrium simulations using the Jarzynski relationship, or by harmonically restraining the ligand at different distances from the binding pocket and then computing a potential of mean force.
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