We postulate that more restrained regions were related to the MHC binding although regions more "flexible" and exposed would contact with the TCR, therefore defining the pMHC specificity (Figure S1).
Furthermore, with the overall accurate prediction of RSA by SABLE, we showed that the method is prone to over-prediction in terms of burial state for residues that are located in trans-membrane regions [ 44], at protein-protein interaction interfaces [ 37], and within structurally restrained regions [ 45].
The dark gray region on the X axis corresponds to a latitudinally restrained region of eastward electrojet (ionospheric electric current flow), and the light gray region to a broad westward electrojet poleward of it.
While the actual path taken by a particular G-protein-GEF complex through this enormous space cannot be predicted, it is likely that a common, more restrained region of the conformational space will envelope most such paths, particularly near the transition state.
We may postulate that the unusual conservation of sequence identity for the region 436 to 746 of TLR1 and TLR6, in all nine mammalian species for which complete sequence information is available, reflects strong selective mechanisms that restrained divergence of this region.
By comparing the probabilities of silent versus missense mutation in these windows, regions of either restrained or excessive mutability were identified as hypo- or hyper-mutable, respectively.
Also, the short address codes for the 1.5K array were carefully selected to have a similar overall length, GC-content, and melting temperature (Tm), whereas for the 24K array the targeted regions were somewhat restrained having been pre-determined by the 50 nucleotide probe sequences on the whole-genome gene expression BeadChip (HumanRef-8 v3).
In contrast, the E-box and control regions (exon) of CCND1 gene promoter showed restrained enrichment in all treated groups (Fig. 4d).
Hilary notes that congressional committees and an interagency group do carefully review who is targeted and that a restrained Obama has not used drones against terrorist camps and regions, though she candidly admits that she wouldn't be so sanguine if Bush-Cheney had made the same decision.
Therefore, the aim of the study was to compare thermal nociceptive thresholds and the performance of a thermode based contact heat test system at different body regions under different environmental conditions and different day times in restrained or free moving horses.
The restrained response reflected the reality of women's lives in the region, it said.
